Patent Number: 6,168,943

Title: Methods for making modified recombinant vesiculoviruses

Abstract: The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable vesiculoviruses, as well as recombinant replicable vesiculoviruses, from cloned DNA, by a method comprising expression of the full-length positive-strand vesiculovirus antigenomic RNA in host cells. The recombinant vesiculoviruses do not cause serious pathology in humans, can be obtained in high titers, and have use as vaccines. The recombinant vesiculoviruses can also be inactivated for use as killed vaccines.

Inventors: Rose; John K. (Guilford, CT)

Assignee: Yale University

International Classification: C07K 14/145 (20060101); C07K 14/005 (20060101); C07K 16/08 (20060101); C07K 16/10 (20060101); C12N 7/00 (20060101); C12N 15/86 (20060101); A61K 39/00 (20060101); A61K 039/205 (); C07H 021/04 (); C07K 014/145 (); C12N 007/01 ()

Expiration Date: 01/02/2018