Patent Number: 6,168,946

Title: gp75 as a tumor vaccine for melanoma

Abstract: The present invention provides an isolated nucleic acid molecule whose sequence encodes the amino acid sequence for gp75 or a fragment thereof. The present invention further provides an isolated cDNA molecule of the gp75 nucleic acid molecule or a fragment thereof and the amino acid sequence derived therefrom. This invention also provides vaccines for stimulating or enhancing in a subject to whom the vaccine is administered production of antibodies directed against gp75. This invention further provides methods using the vaccines of this invention for stimulating or enhancing production of antibodies against gp75 as well as for treating, preventing or delaying the recurrence of cancer.

Inventors: Houghton; Alan N. (New York, NY), Vijayasaradhi; Setaluri (New York, NY)

Assignee: Sloan-Kettering Institute for Cancer Research

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); C12N 9/02 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); C12N 015/12 (); C12N 001/20 (); C12N 005/00 ()

Expiration Date: 01/02/2018