Patent Number: 6,168,950

Title: Antisense modulation of MEKK1 expression

Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK1. Methods of using these compounds for modulation of MEKK1 expression and for treatment of diseases associated with expression of MEKK1 are provided.

Inventors: Monia; Brett P. (La Costa, CA), Gaarde; William (Carlsbad, CA), Ward; Donna T. (San Diego, CA), Cowsert; Lex M. (Carlsbad, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: A61K 48/00 (20060101); C12N 15/11 (20060101); A61K 38/00 (20060101); C07T 021/04 (); C12Q 001/68 (); C12N 015/85 ()

Expiration Date: 01/02/2018