Patent Number: 6,169,073

Title: Peptides and peptidomimetics with structural similarity to human p53 that activate p53 function

Abstract: The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and of select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.

Inventors: Halazonetis; Thanos (Philadelphia, PA), Hartwig; Wolfgang (Stamford, CT)

Assignee: Bayer Corporation

International Classification: A61K 38/17 (20060101); C07K 14/435 (20060101); C07K 14/82 (20060101); C07K 14/47 (20060101); A61K 38/00 (20060101); A61K 038/00 ()

Expiration Date: 01/02/2018