Patent Number: 6,169,075

Title: Cytostatic agents

Abstract: Compounds of formula 1 ##STR1## wherein R.sub.4 is an ester or thioester group, and R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification are inhibitors of rapidly dividing tumour cells.

Inventors: Pearson; Lindsey Ann (Oxford, GB), Ayscough; Andrew Paul (Oxford, GB), Huxley; Philip (Oxford, GB), Drummond; Alan Hastings (Oxford, GB)

Assignee: British Biotech Pharmaceuticals Limited

International Classification: A61K 31/223 (20060101); A61K 31/216 (20060101); A61K 31/21 (20060101); A61K 31/341 (20060101); A61K 31/381 (20060101); A61K 31/4406 (20060101); A61K 31/445 (20060101); C07D 211/46 (20060101); C07C 259/00 (20060101); C07C 259/06 (20060101); C07D 213/00 (20060101); C07D 307/20 (20060101); C07D 307/00 (20060101); C07D 211/00 (20060101); C07D 213/55 (20060101); C07D 333/34 (20060101); C07D 333/00 (20060101); C07K 005/06 ()

Expiration Date: 01/02/2018