Patent Number: 6,169,076

Title: P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols

Abstract: The present invention is directed to salt-free and essentially salt-free p-boronophenylalanine-carbohydrate or p-boronophenylalanine-polyol complexes, as well as methods for making such compounds. In addition, the present invention provides methods for substantially solubilizing freeze-dried p-boronophenylalanine-carbohydrate and p-boronophenylalanine-polyol complexes. The present invention further provides compositions and methods for enhancing the solubility of boronophenylalanine.

Inventors: Shull; Brian (Durham, NC), Spielvogel; David (Raleigh, NC), Head; Gerald (Cary, NC)

Assignee: Glcosyn Pharmaceuticals, Inc.

International Classification: C07B 59/00 (20060101); C07F 5/00 (20060101); C07F 5/02 (20060101); C07H 1/00 (20060101); A61K 031/70 (); C07H 001/00 ()

Expiration Date: 01/02/2018