Patent Number: 6,169,078

Title: Materials and methods for the intracellular delivery of substances

Abstract: The subject invention concerns novel materials and methods for the delivery of substances into cells. In a specific embodiment substances are delivered into cells using a novel class of lipid compounds. These compounds, cationic lipid compounds having a disulfide bond, can be complexed with DNA to be inserted into a cell in gene therapy. Once inside the cell, enzymes present within the cell cleave the disulfide bond and the DNA is released.

Inventors: Hughes; Jeffrey Allen (Gainesville, FL), Tang; Fuxng (Gainesville, FL)

Assignee: University of Florida

International Classification: A61K 47/48 (20060101); A61K 48/00 (20060101); A61K 048/00 ()

Expiration Date: 01/02/2018