Patent Number: 6,169,080

Title: Highly lipophilic camptothecin derivatives

Abstract: This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution at C-7 and a second at one of C-9, C-10, C-11 or C-12. The invention also includes methods of using the compounds as Topoisomerase I inhibitors to treat patients with cancer. The invention also includes pharmaceutical formulations which consist of the novel compounds in solution or suspension with one or more pharmaceutical excipients or dilutes.

Inventors: Hausheer; Frederick H. (Boerne, TX), Haridas; Kochat (San Antonio, TX), Seetharamulu; P. (San Antonio, TX), Reddy; Dasharatha G. (San Antonio, TX), Yao; Shijie (San Antonio, TX), Petluru; Pavankumar N.V. (San Antonio, TX), Murali; Dhanabalan (San Antonio, TX)

Assignee: BioNumerik Pharmaceuticals, Inc.

International Classification: C07F 7/00 (20060101); C07F 7/08 (20060101); C07D 491/00 (20060101); C07D 491/22 (20060101); A61K 031/475 (); A61K 031/695 (); C07D 491/22 (); A61P 035/00 ()

Expiration Date: 01/02/2018