Patent Number: 6,169,085

Title: Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors

Abstract: Selected sulfonylalkanoylamino hydroxyethylamine sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.

Inventors: Getman; Daniel P. (Chesterfield, MO), DeCrescenzo; Gary A. (St. Charles, MO), Freskos; John N. (Clayton, MO), Vazquez; Michael L. (Gurnee, IL), Sikorski; James A. (Des Peres, MO), Devadas; Balekudru (Chesterfield, MO), Nagarajan; Srinivasan (Chesterfield, MO), McDonald; Joseph J. (Ballwin, MO)

Assignee: G. D. Searle & Company

International Classification: C07C 311/29 (20060101); C07C 311/00 (20060101); C07C 317/00 (20060101); C07C 317/44 (20060101); C07C 311/41 (20060101); C07D 235/06 (20060101); C07D 317/00 (20060101); C07D 307/00 (20060101); C07D 307/79 (20060101); C07D 235/32 (20060101); C07D 235/00 (20060101); C07D 303/00 (20060101); C07D 303/36 (20060101); C07D 235/30 (20060101); C07D 319/18 (20060101); C07D 217/00 (20060101); C07D 249/18 (20060101); C07D 319/00 (20060101); C07D 277/62 (20060101); C07D 249/20 (20060101); C07D 215/36 (20060101); C07D 317/62 (20060101); C07D 249/00 (20060101); C07D 215/00 (20060101); C07D 263/00 (20060101); C07D 263/56 (20060101); C07D 277/00 (20060101); C07D 277/82 (20060101); C07D 217/04 (20060101); A61K 031/18 (); A61K 031/343 (); A61K 031/4192 (); C07C 311/17 (); C07C 249/18 (); C07C 307/79 ()

Expiration Date: 01/02/2018