Patent Number: 6,169,087

Title: Modulators of protein tyrosine phosphatases (PTPases)

Abstract: The present invention provides novel compounds of Formula 1 or Formula 2 and compositions thereof, methods of their use, and methods of their manufacture, ##STR1## wherein X, Y, Z, W, R.sub.1, R.sub.2 and R.sub.3 are defined more fully in the description. These compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, and a number of other diseases.

Inventors: Andersen; Henrik Sune (Lyngby, DK), Branner; Sven (Lyngby, DK), Jeppesen; Claus Bekker (Niv.ang., DK), Moeller; Niels Peter Hundahl (Copenhagen, DK), Mjalli; Adnan M. M. (Louisville, KY), Sarshar; Sepehr (San Diego, CA)

Assignee: Novo Nordisk A/S

International Classification: C07D 495/04 (20060101); C07D 495/00 (20060101); A61K 031/4985 (); C07D 237/00 (); C07D 403/02 (); C07D 409/02 ()

Expiration Date: 01/02/2018