Patent Number: 6,169,088

Title: 1,3 diazines with platelet-derived growth factor receptor inhibitory activity

Abstract: 1,3 Diazines and pharmaceutically acceptable salts thereof inhibit phosphorylation of platelet-derived growth factor receptor and thereby hinder abnormal cell growth and cell wandering. The compounds may be used to treat or prevent cell-proliferative disorders such as arteriosclerosis, vascular reobstruction, cancer and glomerulosclerosis.

Inventors: Matsuno; Kenji (Shizouka, JP), Ichimura; Michio (Mishima, JP), Nomoto; Yuji (Shizouka, JP), Fujiwara; Shigeki (Mishima, JP), Ide; Shinichi (Numadzu, JP), Tsukuda; Eiji (Odawara, JP), Irie; Junko (Shizouka, JP), Oda; Shoji (Shizouka, JP)

Assignee: Kyowa Hakko Kogyo Co., Ltd.

International Classification: A61K 31/502 (20060101); A61K 31/496 (20060101); A61K 31/517 (20060101); C07D 237/00 (20060101); C07D 237/34 (20060101); C07D 405/00 (20060101); C07D 403/12 (20060101); C07D 405/12 (20060101); C07D 239/94 (20060101); C07D 217/00 (20060101); C07D 409/12 (20060101); C07D 239/00 (20060101); C07D 215/46 (20060101); C07D 215/00 (20060101); C07D 417/00 (20060101); C07D 401/12 (20060101); C07D 409/00 (20060101); C07D 217/22 (20060101); C07D 417/12 (20060101); C07D 401/00 (20060101); C07D 403/00 (20060101); C07D 487/00 (20060101); C07D 487/04 (20060101); A61K 031/495 (); C07D 487/04 ()

Expiration Date: 01/02/2018