Patent Number: 6,169,090

Title: Heterocyclic compounds and their therapeutic use

Abstract: The compound, according to formula (i) ##STR1## wherein X and Y are independently CH, N or N-oxide, provided that X and Y do not both represent CH; Z is CO or CS; R.sub.1 is alkyl, optionally substituted with one or more halogens; and R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each various organic groups. Such compounds have therapeutic utility, via inhibition of phosphodiesterase IV.

Inventors: Dyke; Hazel Joan (Cambridge, GB), Sabin; Verity Margaret (Cambridge, GB), Sharpe; Andrew (Cambridge, GB), Haughan; Alan Findlay (Cambridge, GB), Lowe; Christopher (Cambridge, GB), Buckley; George (Cambridge, GB), Montana; John (Cambridge, GB)

Assignee: Darwin Discovery, Ltd.

International Classification: C07D 491/04 (20060101); C07D 491/00 (20060101); C07D 491/048 (); A61K 031/44 ()

Expiration Date: 01/02/2018