Patent Number: 6,169,095

Title: Bradykinin antagonist quinolines

Abstract: The invention relates to a pharmaceutical composition for ophthalmic administration comprising a compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, X.sup.3, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, Q and A are as defined in the disclosure. This invention also relates to methods of using the pharmaceutical composition in the prevention and/or treatment of bradykinin or its analogues mediated diseases in the eye, such as allergy, inflammation and pain of the eye.

Inventors: Oku; Teruo (Tsukuba, JP), Kayakiri; Hiroshi (Tsukuba, JP), Satoh; Shigeki (Tsukuba, JP), Abe; Yoshito (Inashiki-gun, JP), Sawada; Yuki (Tsukuba, JP), Inoue; Takayuki (Tsukuba, JP), Tanaka; Hirokazu (Takarazuka, JP)

Assignee: Fujisawa Pharmaceutical Co., Ltd.

International Classification: C07D 237/00 (20060101); C07D 241/00 (20060101); C07D 239/74 (20060101); C07D 237/28 (20060101); C07D 241/42 (20060101); C07D 403/12 (20060101); C07D 413/12 (20060101); C07F 7/00 (20060101); C07D 409/12 (20060101); C07D 413/00 (20060101); C07D 239/00 (20060101); C07D 215/26 (20060101); C07D 215/00 (20060101); C07D 401/14 (20060101); C07D 401/12 (20060101); C07D 409/00 (20060101); C07D 401/00 (20060101); C07D 403/00 (20060101); C07F 7/18 (20060101); A61K 031/47 (); C07D 215/12 ()

Expiration Date: 01/02/2018