Patent Number: 6,169,103

Title: Fluorine-substituted biphenyl butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Abstract: Fluorine-substituted biphenyl butyric acid compounds and derivatives are described as well as acid methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, stromelysin-1, and collagenase-3, and for the treatment of atherosclerotic plaque rupture, aortic aneurism, heart failure, restenosis, periodontal disease, corneal ulceration, treatment of burns, decubital ulcers, wound healing, cancer, inflammation, pain, arthritis, osteoporosis, multiple sclerosis, renal disease, and other autoimmune or inflammatory disorders dependent upon tissue invasion by leukocytes or other activated migrating cells, acute and chronic neurodegenerative disorders including stroke, head trauma, spinal cord injury, Alzheimer's disease, amyotrophic lateral sclerosis, cerebral amyloid angiopathy, AIDS, Parkinson's disease, Huntington's disease, prion diseases, myasthenia gravis, and Duchenne's muscular dystrophy.

Inventors: Purchase, Jr.; Claude Forsey (Ann Arbor, MI), Roth; Bruce David (Plymouth, MI), Schielke; Gerald Paul (Ann Arbor, MI), Walker; Lary Craswell (Ann Arbor, MI), White; Andrew David (Pinckney, MI)

Assignee: Warner-Lambert

International Classification: A61K 31/275 (20060101); A61K 31/40 (20060101); C07C 327/58 (20060101); C07C 251/48 (20060101); C07C 251/00 (20060101); C07C 255/00 (20060101); C07C 255/64 (20060101); C07C 327/00 (20060101); A61K 031/40 (); A61K 031/275 (); C07D 209/48 ()

Expiration Date: 01/02/2018