Patent Number: 6,169,104

Title: Di-aryl ethers and their derivatives as anti-cancer agents

Abstract: The present invention relates, inter alia, to compounds that bind tubulin and exhibit anti-mitotic properties and to methods of using such compounds to inhibit abnormal cell mitosis and, in particular, to inhibit tumor cell growth. In addition, methods are presented of treating mammalian diseases associated with undesired and uncontrolled angiogenesis.

Inventors: Tuse ; Daniel (Menlo Park, CA), Chen; Xiaoying (Newark, CA), Hiebert; Charles K. (Sunnyvale, CA), Olsen; Cris M. (Soquel, CA), Laderoute; Keith (Palo Alto, CA), Waleh; Nahid (Palo Alto, CA), Knapp; A. Merrill (Menlo Park, CA)

Assignee: Large Scale Biology Corporation

International Classification: A61K 41/00 (20060101); A61K 31/09 (20060101); A61K 31/085 (20060101); A61K 31/095 (20060101); A61K 31/10 (20060101); A61K 31/11 (20060101); A61K 31/185 (20060101); A61K 31/075 (20060101); A61K 31/12 (20060101); A61K 31/21 (20060101); A61K 31/192 (20060101); A61K 31/235 (20060101); C07C 205/00 (20060101); C07C 205/59 (20060101); C07C 47/575 (20060101); C07C 45/29 (20060101); C07C 45/00 (20060101); C07C 47/52 (20060101); C07C 65/24 (20060101); C07C 65/00 (20060101); A61K 031/415 ()

Expiration Date: 01/02/2018