Patent Number: 6,169,106

Title: Indolinones having kinase inhibitory activity

Abstract: The present invention relates to substituted indolinones of general formula ##STR1## wherein R.sub.1 to R.sub.5, and X are defined as in claim 1, the isomers thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, particularly an inhibitory effect on various kinases and cycline/CDK complexes and on the proliferation of various tumour cells, pharmaceutical compositions containing these (compounds, their use and processes for preparing them.

Inventors: Heckel; Armin (Biberach, DE), Walter; Rainer (Biberach, DE), Grell; Wolfgang (Biberach, DE), van Meel; Jacobus C. A. (Mittelbiberach, DE), Redemann; Norbert (Biberach, DE)

Assignee: Boehringer Ingelheim Pharma KG

International Classification: C07D 209/00 (20060101); C07D 209/04 (20060101); A61K 031/404 (); C07D 209/04 ()

Expiration Date: 01/02/2018