Patent Number: 6,169,166

Title: Polynucleotide and polypeptide sequences encoding rat mdr1b2 and screening methods thereof

Abstract: Rat mdr1b2 polypeptides and polynucleotides and method for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for screening for compounds which either agonize or antagonize rat mdr1b2. Further disclosed is method for performing a selection screen, whereby compounds are discovered that neither agonize nor antagonize rat mdr1b2.

Inventors: Brun; Kimberly A. (Harleysville, PA), Chenery; Richard J (Hitchin, GB), Ellens; Harma (Norristown, PA), Feild; John A (Wayne, PA), Yue; Lin (Phoenixville, PA)

Assignee: SmithKline Beecham Corporation

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C07K 001/00 ()

Expiration Date: 01/02/2018