Patent Number: 6,169,168

Title: Erythromycin A derivatives

Abstract: An erythromycin A derivative represented by the formula: ##STR1## wherein n is an integer of from 1 to 8, R.sup.1 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, R.sup.2 is a pyridylmethyl group, a quinolylmethyl group, a pyridylsulfonyl group or quinolylsulfonyl group, R.sup.3 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a cinnamyl group, R.sup.4 is a cladinosyloxy group or a group represented by the formula: ##STR2## wherein m is 0 or 1, R.sub.5 is a pyridyl group, a quinolyl group, a phenyl group, a phenyl group substituted with one, two or three members selected from alkyl groups having 1 to 6 carbon atoms, a nitro group, alkoxy groups having 1 to 3 carbon atoms and halogen atoms, or a pyridyl or quinolyl group substituted with one or two members selected from alkyl groups having 1 to 6 carbon atoms, a nitro group, alkoxy groups having 1 to 3 carbon atoms and halogen atoms; or a pharmaceutically acceptable salt thereof.

Inventors: Asaka; Toshifumi (Tokyo, JP), Kashimura; Masato (Tokyo, JP), Sugimoto; Tomohiro (Tokyo, JP), Tanikawa; Tetsuya (Tokyo, JP), Ishii; Takaaki (Tokyo, JP), Matsuura; Akiko (Tokyo, JP)

Assignee: Taisho Pharmaceuticals Co., Ltd.

International Classification: C07H 17/00 (20060101); C07H 17/08 (20060101); C07H 017/08 ()

Expiration Date: 01/02/2018