Patent Number: 6,169,169

Title: PNA probes for detection of Neisseria gonorrhoeae and Chlamydia trachomatis

Abstract: Specific peptide nucleic acid (PNA) probes for detecting a sexual transmitted disease caused by Neisseria gonorrhoeae or Chlamydia trachomatis comprising N-(2-aminoethyl)glycine units in amide linkage with the glycine nitrogen connected to naturally occurring nucleobases or non-naturally occurring nucleobases by a methylene carbonyl linker and said probes capable of hybridizing to 16S or 23S rRNA or rDNA of Neisseria gonorrhoeae or Chlamydia trachomatis are described. PNA is a very stable molecule with very high affinity for nucleic acid allowing a PNA probe to be shorter than conventional nucleic acid probes.

Inventors: Hyldig-Nielsen; Jens J.o slashed.rgen (Vanl.o slashed.se, DK), Godskesen; Michael Anders (Vedb.ae butted.k, DK)

Assignee: DAKO A/S

International Classification: C07K 14/22 (20060101); C07K 14/195 (20060101); C07K 14/00 (20060101); C07K 14/295 (20060101); C12Q 1/68 (20060101); C12Q 001/68 (); C07H 019/00 (); C07H 021/02 (); A01N 043/04 ()

Expiration Date: 01/02/2018