Patent Number: 6,169,179

Title: Method for manufacturing (3S,4R)-4-[(R)-1'-formylethyl]azetidin-2-one derivatives

Abstract: A method for manufacturing (3S,4R)-4-[(R)-1'-formylethyl]azetidin-2-one derivatives represented by formula (3) wherein R.sup.1 represents a hydrogen atom or a protective group, through asymmetric hydroformylation of 4-vinylazetidin-2-one represented by formula (1) wherein R.sup.1 has the same meaning as described above; in the presence of a rhodium complex and a (2S,4S)-diphosphine compound represented by formula (2) wherein R.sup.2 represents a phenyl group which may be substituted with 1-5 substituent(s) selected from a lower alkyl group, a lower alkoxy group, and a halogen atom. ##STR1## By use of both an inexpensive optically active diphosphine compound and a rhodium complex as catalysts, intermediate compounds important for carbapenem antibiotics can be manufactured with high selectivity and efficiency.

Inventors: Alper; Howard (Ottawa, CA), Saito; Takao (Hiratsuka, JP), Miura; Takashi (Hiratsuka, JP)

Assignee: Takasago International Corporation

International Classification: C07D 205/08 (20060101); C07D 205/00 (20060101); C07D 205/00 (); C07F 009/02 ()

Expiration Date: 01/02/2018