Patent Number: 6,169,181

Title: Compounds useful to treat retroviral infections

Abstract: The present invention relates to compounds of formula I and II which are pyran-2-ones, 5,6-dihydro-pyran-2-ones, 4-hydroxy-benzopyran-2-ones, 4-hydroxy-cycloalkyl[b]pyran-2-ones, and derivatives thereof, useful for inhibiting a retrovirus in a mammalian cell infected with said retrovirus. ##STR1## wherein R.sub.10 and R.sub.20 taken together are: ##STR2##

Inventors: Romines; Karen Rene (Paw Paw, MI), Bundy; Gordon L. (Portage, MI), Schwartz; Theresa M. (Kalamazoo, MI), Tommasi; Ruben A. (Whitehouse Station, NJ), Strohbach; Joseph W. (Mendon, MI), Turner; Steven Ronald (Kalamazoo, MI), Thaisrivongs; Suvit (Kalamazoo, MI), Aristoff; Paul Adrian (Kalamazoo, MI), Johnson; Paul D. (Portage, MI), Skulnick; Harvey Irving (Kalamazoo, MI), Skaletzky; Louis L. (Kalamazoo, MI), Anderson; David John (Kalamazoo, MI), Morris; Joel (Kalamazoo, MI), Gammill; Ronald B. (Portage, MI), Luke; George P. (Lexington, MA)

Assignee: Pharmacia & Upjohn Company

International Classification: C07D 311/74 (20060101); C07D 405/14 (20060101); C07D 405/00 (20060101); C07D 405/12 (20060101); C07D 311/00 (20060101); C07D 309/00 (20060101); C07D 309/32 (20060101); C07D 309/38 (20060101); C07D 311/02 (20060101); C07D 307/77 (); C07D 277/04 (); C07D 455/02 (); C07D 401/00 ()

Expiration Date: 01/02/2018