Patent Number: 6,169,188

Title: (Methylsulfonyl)phenyl-2-(5H)-furanones as COX-2 inhibitors

Abstract: The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

Inventors: Belley; Michel (Pierrefonds, CA), Gauthier; Jacques Yves (Laval, CA), Grimm; Erich (Baie d'Urfe, CA), LeBlanc; Yves (Kirkland, CA), Li; Chun-Sing (Dollard des Ormeaux, CA), Therien; Michel (Laval, CA), Black; Cameron (Pointe Claire, CA), Prasit; Petpiboon (Kirkland, CA), Lau; Cheuk-Kun (Ile Bizard, CA), Roy; Patrick (Dollard des Ormeaux, CA)

Assignee: Merck Frosst Canada & Co.

International Classification: C07C 317/24 (20060101); C07C 317/00 (20060101); C07D 307/83 (20060101); C07D 307/66 (20060101); C07D 307/00 (20060101); C07D 307/60 (20060101); C07D 307/58 (20060101); C07D 307/62 (20060101); C07D 405/00 (20060101); C07D 405/12 (20060101); C07D 409/12 (20060101); C07D 307/68 (20060101); C07D 307/64 (20060101); C07D 513/00 (20060101); C07D 307/94 (20060101); C07D 513/04 (20060101); C07D 417/00 (20060101); C07D 471/00 (20060101); C07D 409/00 (20060101); C07D 417/12 (20060101); C07D 491/04 (20060101); C07D 495/04 (20060101); C07D 495/00 (20060101); C07D 471/04 (20060101); C07D 491/00 (20060101); C07D 498/00 (20060101); C07D 498/04 (20060101); C07D 317/44 ()

Expiration Date: 01/02/2018