Patent Number: 6,200,546

Title: Gastrin receptor-avid peptide conjugates

Abstract: A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a neoplastic disease includes administering to the subject an effective amount of a radiopharmaceutical having a metal chelated with a chelating group attached to a moiety capable of binding to a gastrin releasing peptide receptor expressed on tumor cells with subsequent internalization inside of the cell. A method of forming a therapeutic or diagnostic compound includes reacting a metal synthon with a chelating group covalently linked with a moiety capable of binding a gastrin releasing peptide receptor.

Inventors: Hoffman; Timothy J. (Columbia, MO), Volkert; Wynn A. (Columbia, MO), Li; Ning (Baltimore, MD), Sieckman; Gary (Ashland, MO), Higginbotham; C. A. (Columbia, MO)

Assignee: The Curators of the University of Missouri

International Classification: A61K 51/02 (20060101); A61K 51/08 (20060101); A61K 049/00 ()

Expiration Date: 03/13/2018