Patent Number: 6,200,558

Title: Biopolymer-bound nitric oxide-releasing compositions, pharmaceuticalcompositions incorporating same and methods of treating biologicaldisorders using same

Abstract: A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.

Inventors: Saavedra; Joseph E. (Thurmont, MD), Keefer; Larry K. (Bethesda, MD), Roller; Peter P. (Rockville, MD), Akamatsu; Miki (Rockville, MD)


International Classification: A61K 47/48 (20060101); C08F 8/30 (20060101); C08F 8/00 (20060101); A61K 047/48 (); A61K 031/395 (); A61L 027/22 ()

Expiration Date: 03/12013