Patent Number: 6,200,566

Title: Anti-endoglin monoclonal antibodies and their use in antiangiogenic therapy

Abstract: A monoclonal antibody, or fragments thereof, having binding specificity for both endoglin expressed on human vascular endothelial cells and on murine endothelial cells. Antiangiogenic therapy in mammals can be effected by administering to the mammalian host a therapeutically effective amount of an anti-endoglin monoclonal antibody, or fragment thereof, which is conjugated to at least one angiogenesis inhibitor or antitumor agent. The composition is useful for treating tumor and angiogenesis-associated diseases.

Inventors: Seon; Ben K. (Williamsville, NY)

Assignee: Health Research, Inc.

International Classification: A61K 47/48 (20060101); C07K 16/28 (20060101); C07K 16/18 (20060101); A61K 38/00 (20060101); A01K 039/395 (); A01K 039/40 (); A01K 039/42 (); C07K 001/00 (); C07K 014/00 ()

Expiration Date: 03/13/2018