Patent Number: 6,200,567

Title: Therapeutic agents as cytokine antagonists and agonists

Abstract: A therapeutic agent capable of of binding to the F'-G' loop of domain 4 of the common .sub.c Chain of the receptor for GM-CSF, IL-3, and IL-5. The amino acid Tyr.sup.421 which is located in the F'-G' loop is critical in the high affinity binding and stimulation of function of GM-CSF, IL-3 and IL-5 to the common .sub.c chain of the receptors. Other receptors for cytokines also show hydrophobic amino acids in analogous positions and it is probable that they too play a pivotal role in binding of respective cytokines to them and in modulating function. Agents capable of binding to the F'-G' loops are suggested and should be of therapeutic value.

Inventors: Lopez; Angel (Adelaide, AU), Bagley; Christopher (Adelaide, AU), Woodcock; Joanna (Adelaide, AU)

Assignee: Medvet Science Pty Ltd

International Classification: C07K 14/435 (20060101); C07K 14/705 (20060101); C07K 14/715 (20060101); A61K 38/00 (20060101); A61K 039/395 (); G01N 033/53 (); C07K 016/28 ()

Expiration Date: 03/13/2018