Patent Number: 6,200,745

Title: Vitro assay system using a human cell line for testing the effectiveness of anti-papilloma viral agents

Abstract: An in vitro method for testing the effectiveness of antiviral agents is provided. The method allows for screening anti-papillomavirus drugs which can interfere with the early and maintenance stages of papillomavirus infection. The method comprises growing epithelial cells susceptible to infection with papillomavirus in a monolayer system and measuring the effectiveness of various agents present in the growing media to interfere with the growth of the virus. The method is free from interferences caused by the regional variability, since the cell cultures are evenly dispersed monolayers.

Inventors: Kreider; John W. (Palmyra, PA), Angell; Michael G. (Hamburg, MI), Smith; Loyd H. (Davis, CA), Hitchcock; Margaret (Davis, CA), Foster; Chris (Carmichael, CA), Isseroff; Roslyn Rivkah (Sacramento, CA)

Assignee: The Penn State Research Foundation

International Classification: G01N 33/50 (20060101); C12Q 001/68 (); C12Q 001/70 ()

Expiration Date: 03/13/2018