Patent Number: 6,207,150

Title: Variants of thymidine kinase, nucleic acids encoding them, and methods of using them

Abstract: The present invention relates to a nucleic acid sequence characterized in that it is derived from the wild nucleic acid sequence coding for a thymidine kinase, said nucleic acid sequence having at least one mutation in the region corresponding to the ATP binding site and conveniently a second mutation in the N-terminal region and/or C-terminal region. It also relates to variants of the wild thymidine kinase and their use in genic therapy.

Inventors: Crouzet; Joel (Sceaux, FR), Blanche; Francis (Paris, FR), Couder; Michel (Sucy en Brie, FR), Cameron; Beatrice (Paris, FR)

Assignee: Aventis Pharma S.A.

International Classification: C12N 9/12 (20060101); A61K 38/00 (20060101); A61K 038/51 (); C12N 009/12 (); C12N 015/00 (); C07H 021/04 (); C12Q 001/68 ()

Expiration Date: 03/27/2018