Patent Number: 6,251,099

Title: Compound delivery using impulse transients

Abstract: A method for delivering compounds through epithelial cell layers using impulse transients is described. The method involves applying a compound to, e.g., the stratum corneum, of a patient and then inducing impulse transients to create transient increases in the permeability of epithelial tissue, thereby facilitating delivery of the compound across the epithelial cell layer.

Inventors: Kollias; Nikiforos (Watertown, MA), Doukas; Apostolos G. (Belmont, MA), Flotte; Thomas J. (Boston, MA), McAuliffe; Daniel J. (Boxford, MA), Lee; Shun (Boston, MA)

Assignee: The General Hospital Corporation

International Classification: A61M 37/00 (20060101); A61N 1/32 (20060101); A61B 17/00 (20060101); A61N 1/30 (20060101); A61N 001/30 ()

Expiration Date: 06/26/2018