Patent Number: 6,251,129

Title: Method for low temperature thrombolysis and low temperature thrombolytic agent with selective organ temperature control

Abstract: The invention provides a method for substantially reducing the size of a thrombus in a blood vessel in which blood is flowing. The method includes delivering a heat transfer element to a blood vessel in fluid communication with a thrombosed blood vessel. The temperature of the heat transfer element is adjusted such that the same is sufficient to remove heat from the flowing blood. Heat is transferred from a volume including the thrombus to the heat transfer element. In a separate embodiment, heat may be delivered to the volume including the thrombus from the heat transfer element. The resultant temperature of the volume may be sufficient to substantially reduce the size of a thrombus. For example, the resultant temperature of the volume may be sufficiently high to substantially enhance plasminogen activation near the thrombus. In a separate embodiment, a therapeutic drug may be delivered to the blood vessel to further reduce the size of a thrombus, the drug having an optimal temperature at the hypothermic or hyperthernic temperature of the blood.

Inventors: Dobak, III; John D. (La Jolla, CA), Lasheras; Juan C. (La Jolla, CA)

Assignee: Innercool Therapies, Inc.

International Classification: A61M 25/00 (20060101); A61F 7/12 (20060101); A61F 7/00 (20060101); A61F 007/00 ()

Expiration Date: 06/26/2018