Patent Number: 6,251,355

Title: Fine cisplatin powder and process for the production thereof

Abstract: The present invention relates to a novel fine cisplatin powder utilized as an anticancer agent. The fine cisplatin powder obtained in the present invention does not cause secondary agglomeration, is excellent in fluidity and easily handleable in the pharmaceutical preparation step. Furthermore, the fine cisplatin powder is reduced in the content of N,N-dimethylformamide as the residual solvent, and can be dissolved rapidly in physiological saline, thus being suitable for cancer therapy particularly by intra-arterial injection. This fine powder can be produced by contriving specified means for crystallizing cisplatin from a solution thereof in N,N-dimethylformamide.

Inventors: Murata; Toshitaka (Saitama, JP), Ishikawa; Keizou (Saitama, JP), Kogawa; Osamu (Chiba, JP), Iwata; Kenji (Saitama, JP)

Assignee: Nippon Kayaku Kabushiki Kaisha

International Classification: A61K 33/24 (20060101); A61K 9/14 (20060101); A61K 31/28 (20060101); A61K 31/282 (20060101); C01G 55/00 (20060101); C01B 021/00 ()

Expiration Date: 06/26/2018