Patent Number: 6,251,362

Title: Method of establishing the optimal radiation dose

Abstract: A method for determining the number of millicuries to be administered to a patient so as to deliver a given centigray (cGy) dose to either the patient's lean body or the patient's total body. The method includes the steps of injecting a radioactive tracer into a patient, determining radiation levels in the whole body, calculating a geometric mean based on the radiation levels, determining the percent-injected activity remaining in the body at each time point, plotting the percent-injected activity versus calculated time from infusion on a log-linear graph, determining the effective half live and the rate of clearance from the log-linear graph, cross-indexing the effective half-life value with the patient's body weight, and multiplying the determined amount of therapeutic millicuries per centigray by the amount of desired centigray to be administered.

Inventors: Wahl; Richard L. (Ann Arbor, MI), Zasadny; Kenneth R. (Wyandotte, MI)

Assignee: The Regents of the University of Michigan

International Classification: A61K 51/10 (20060101); A61K 51/02 (20060101); A61N 5/10 (20060101); A61K 051/00 (); A61N 005/00 ()

Expiration Date: 06/26/2018