Patent Number: 6,251,364

Title: Ternary ligand complexes useful as radiopharmaceuticals

Abstract: This invention relates to novel radiopharmaceuticals comprised of highly functionalized pyridine ligated technetium-99m labeled HYNIC-biomolecules that selectively localize at sites of disease and thus allow an image to be obtained of the loci using gamma scintigraphy. The invention also provides methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders such as thromboembolic disease or atherosclerosis, infectious disease and cancer.

Inventors: Liu; Shuang (Chelmsford, MA)

Assignee: DuPont Pharmaceuticals Company

International Classification: A61K 51/02 (20060101); A61K 51/08 (20060101); C07K 7/64 (20060101); C07F 13/00 (20060101); C07K 7/52 (20060101); C07K 7/00 (20060101); A61K 051/00 (); C07F 005/00 ()

Expiration Date: 06/26/2018