Patent Number: 6,251,382

Title: Biodegradable high molecular weight polymeric linkers and their conjugates

Abstract: Polymeric compounds of the formula: wherein (m) and (n) independently selected positive integers, preferably from about 1 to about 6 each; D is a residue of a biologically active moiety; M is a multifunctional linker/spacer moiety; and R.sub.1 is a polymer residue are disclosed. Methods of preparing the same and methods of treatment using the same are also included as part of the present invention.

Inventors: Greenwald; Richard B. (Somerset, NJ), Martinez; Anthony J. (Hamilton Square, NJ), Choe; Yun H. (Piscataway, NJ), Pendri; Annapurna (Middletown, CT)

Assignee: Enzon, Inc.

International Classification: A61K 47/48 (20060101); A61K 047/48 ()

Expiration Date: 06/26/2018