Patent Number: 6,251,387

Title: Topoisomerase I

Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding streptococcal topoisomerase I and for detecting the polypeptide in a host.

Inventors: Gwynn; Michael N. (Chester Springs, PA), Kallender; Howard (King of Prussia, PA)

Assignee: SmithKline Beecham Corporation

International Classification: C12N 9/90 (20060101); C12Q 1/68 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); A61K 038/51 (); C12N 009/90 (); C12N 001/20 (); C12N 015/00 (); C07H 021/04 ()

Expiration Date: 06/26/2018