Patent Number: 6,251,396

Title: Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein

Abstract: The present invention is directed toward peptide analogs of human myelin basic protein. The peptide analog is at least seven amino acids long and derived from residues 83 to 99 of human myelin basic protein. The analogs are altered from the native sequence at least at positions 91, 95, or 97. Additional alterations may be made at other positions. Pharmaceutical compositions containing these peptide analogs are provided. The peptide analogs are useful for treating multiple sclerosis.

Inventors: Gaur; Amitabh (San Diego, CA), Conlon; Paul (Solana Beach, CA), Ling; Nicholas C. (San Diego, CA), Staehelin; Theophil (Arlesheim, CH), Crowe; Paul D. (Encinitas, CA)

Assignee: Neurocrine Biosciences, Inc.

International Classification: C07K 14/435 (20060101); C07K 14/47 (20060101); A61K 38/00 (20060101); A61K 039/00 (); A61K 038/17 (); C07K 007/08 (); C07K 014/47 ()

Expiration Date: 06/26/2018