Patent Number: 6,251,397

Title: Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same

Abstract: The present invention provides a purified preparation containing, for example, a polynucleic acid encoding at least one polypeptide selected from the group consisting of proteins encoded by one or more open reading frames (ORF's) of an Iowa strain of porcine reproductive and respiratory syndrome virus (PRRSV), antigenic regions of such proteins which are at least 5 amino acids in length and which effectively protect a porcine host against a subsequent challenge with a PRRSV isolate, and combinations thereof in which amino acids non-essential for antigenicity may be conservatively substituted. The present invention also concerns a polypeptide encoded by such a polynucleic acid; a vaccine comprising an effective amount of such a polynucleic acid or protein; antibodies which specifically bind to such a polynucleic acid or protein; methods of producing the same; and methods of protecting a pig against a PRRSV and treating a pig infected by a PRRSV.

Inventors: Paul; Prem S. (Ames, IA), Meng; Xiang-Jin (Ames, IA), Halbur; Patrick (Ames, IA), Morozov; Igor (Ames, IA)

Assignee: Iowa State University Research Foundation, Inc.

International Classification: A61K 39/12 (20060101); C07K 14/005 (20060101); C07K 14/08 (20060101); C12N 7/00 (20060101); G01N 33/569 (20060101); A61K 38/00 (20060101); A61K 39/00 (20060101); A61K 039/12 ()

Expiration Date: 06/26/2018