Patent Number: 6,251,399

Title: Immuno-reactive peptide CTL epitopes of human cytomegalovirus

Abstract: The invention provides a plurality of peptides (and immunologically functional variants thereof) which are immunogenic epitopes recognized by CD8.sup.+ class I MHC restricted cytotoxic T-lymphocytes of patients harboring latent cytomegalovirus (HCMV) infection. The peptides are capable of activating CTLs and CTLp's in the absence of active viral replication, and thus are useful for eliciting a cellular immune response against HCMV by normal and immunodeficient subjects. Polypeptide and lipopeptide vaccines, with and without adjuvants, also are disclosed.

Inventors: Diamond; Don Jeffrey (Glendora, CA), York; Joanne (Lancaster, CA)


International Classification: A61K 39/245 (20060101); A61K 39/00 (20060101); C07K 14/005 (20060101); C07K 14/045 (20060101); G01N 33/569 (20060101); A61K 38/00 (20060101); A61K 039/245 (); A61K 039/12 (); A61K 038/04 (); A61K 035/26 ()

Expiration Date: 06/26/2018