Patent Number: 6,251,405

Title: Immunological combination compositions and methods

Abstract: Immunological compositions and methods for making and using them. The compositions contain an antigen and a lipoprotein and optionally an adjuvant. The lipoprotein can itself be antigenic or immurogenic. The antigen can be influenza HA and the lipoprotein a recombinantly expressed product having an OspA leader for lipidation and PspA for the protein portion. The antigen can be OspC and the lipoprotein OspA. The components of the composition are co-administered. A potentiated immunological response is obtained by the compositions and methods.

Inventors: Becker; Robert S. (Henryville, PA), Huebner; Robert C. (Stroudsburg, PA), Gray; Maryann B. (Bartonsville, PA), Biscardi; Karen S. (South Sterling, PA)

Assignee: Connaught Laboratories, Inc.

International Classification: A61K 39/102 (20060101); C07K 14/20 (20060101); C07K 14/195 (20060101); C07K 14/285 (20060101); C07K 14/315 (20060101); A61K 39/00 (20060101); A61K 039/02 (); A61K 051/00 (); A61K 039/38 (); A61K 039/116 ()

Expiration Date: 06/26/2018