Patent Number: 6,251,406

Title: Attenuated microorganism strains and their uses

Abstract: This application relates to the use of attenuated prokaryotic miccrooganism strains (such as Salmonella) expressing nucleic acid encoding HPV proteins as vaccines against HPV infection and he associated increased risk of cancer. In particular, the work shows that it is possible to assemble VLPs in a prokaryotic organism and that nasal immunization of mice with the strains HPV-specific conformationally dependent and neutralizing antibodies in serum and genital secretions. The experiments described herein show that it is also possible to assemble chimeric VLPs of a HPV including a fusion partner and that tumor protection can be induced.

Inventors: Haefliger; Denise N. (Lausanne, CH), Kraehenbuhl; Jean-Pierre (Rivaz, CH)

Assignee: BTG International Limited

International Classification: C07K 14/005 (20060101); C07K 14/025 (20060101); C12N 15/74 (20060101); A61K 39/00 (20060101); A61K 039/112 ()

Expiration Date: 06/26/2018