Patent Number: 6,251,427

Title: Pharmaceutical capsule compositions containing loratadine and psuedoephedrine

Abstract: A pharmaceutical capsule composition for oral administration exhibiting controllable, satisfactory release profiles of both loratadine and pseudoephedrine or its salts, which comprises: (a) a plurality of rapid-release pellets (pellets A), each pellet containing (i) a therapeutically effective amount of loratadine, (ii) pseudoephedrine or a pharmaceutically acceptable salt thereof, and (iii) one or more pharmaceutically acceptable excipients; and (b) a plurality of extended-release pellets (pellets B), each pellet containing (i) pseudoephedrine or a pharmaceutically acceptable salt thereof and (ii) one or more pharmaceutically acceptable excipients, which are coated with a water-insoluble polymer in an amount ranging from 2 to 30 wt % and a wet-blocking agent selected from the group consisting of magnesium stearate, talc, fatty acid ester and a mixture thereof in an amount ranging from 2 to 30 wt %, based on the total weight of pellets B.

Inventors: Kim; Hyun-Soo (Kyonggi-do, KR), Park; Young-Joon (Kyonggi-do, KR), Jo; Hang-Bum (Suwon-si, KR)

Assignee: Yuhan Corporation

International Classification: A61K 9/50 (20060101); A61K 31/445 (20060101); A61K 9/16 (20060101); A61K 009/48 (); A61K 009/52 (); A61K 009/54 ()

Expiration Date: 06/26/2018