Patent Number:
6,251,429
Title:
Programmed release ambroxol--HCl dosage forms
Abstract:
Programmed-release ambroxol.multidot.HCl pharmaceutical dosage forms, adopted to maintain a therapeutically effective plasma level thereof for about 24 hours, comprise a plurality of inert core microgranules of a variety of particle sizes ranging from 0.3 to 1.2 mm, such inert core microgranules being coated with alternating microlayers of (1) micronized ambroxol hydrochloride active agent and (2) delayed-release film material, such coated microgranules including an external microlayer of delayed-release film material, and such coated mi.crogranules having particle sizes ranging from 0.6 to 1.5 mm.
Inventors:
Veronesi; Paolo Alberto (Milan, IT), Veronesi; Anna Maria (Milan, IT)
Assignee:
Therapicon slr
International Classification:
A61K 31/135 (20060101); A61K 9/16 (20060101); A61K 009/16 (); A61K 009/50 (); A61K 031/135 ()
Expiration Date:
06/26/2018