Patent Number: 6,251,429

Title: Programmed release ambroxol--HCl dosage forms

Abstract: Programmed-release ambroxol.multidot.HCl pharmaceutical dosage forms, adopted to maintain a therapeutically effective plasma level thereof for about 24 hours, comprise a plurality of inert core microgranules of a variety of particle sizes ranging from 0.3 to 1.2 mm, such inert core microgranules being coated with alternating microlayers of (1) micronized ambroxol hydrochloride active agent and (2) delayed-release film material, such coated microgranules including an external microlayer of delayed-release film material, and such coated mi.crogranules having particle sizes ranging from 0.6 to 1.5 mm.

Inventors: Veronesi; Paolo Alberto (Milan, IT), Veronesi; Anna Maria (Milan, IT)

Assignee: Therapicon slr

International Classification: A61K 31/135 (20060101); A61K 9/16 (20060101); A61K 009/16 (); A61K 009/50 (); A61K 031/135 ()

Expiration Date: 06/26/2018