Patent Number: 6,251,433

Title: Polycationic polymers

Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Inventors: Zuckermann; Ronald N. (Berkeley, CA), Dubois-Stringfellow; Nathalie (Berkeley, CA), Dwarki; Varavani (Alameda, CA), Innis; Michael A. (Moraga, CA), Murphy; John E. (Oakland, CA), Cohen; Fred E. (San Francisco, CA), Uno; Tetsuo (San Francisco, CA)

Assignee: Chiron Corporation

International Classification: A61K 38/22 (20060101); A61K 47/48 (20060101); A61K 48/00 (20060101); C12N 15/87 (20060101); A61F 009/14 ()

Expiration Date: 06/26/2018