Patent Number: 6,251,579

Title: Oxidative stabilization of collagen containing materials

Abstract: This invention relates, in general, to a process for cross-linking and stabilizing proteinaceous material, and in particular, to a process for oxidizing collagenous material, by oxidizing the tissue. The invention also relates to the resulting cross-linked product. The method comprises immersing the material to be cross-linked in a solution comprising compounds designed to generate the radical species singlet oxygen or other oxidizing intermediates without the addition of an external energy source. Immersing collagen containing tissue in a solution comprising an oxidizing agent and sufficient dissolved oxygen, under controlled conditions of pH and temperature, provides a cross-linked and stabilized collagen containing tissue that resists chemical and enzymatic degradation.

Inventors: Moore; Mark A. (Austin, TX), Phillips; Richard E. (San Marcos, TX), Robinson; Melanie D. (Spicewood, TX)

Assignee: Sulzer Carbomedics Inc.

International Classification: A01N 1/02 (20060101); A61L 27/00 (20060101); A61L 27/24 (20060101); C08H 1/06 (20060101); C08H 1/00 (20060101); A01N 001/02 ()

Expiration Date: 06/26/2018