Patent Number: 6,251,582

Title: Alternative G-coupled receptors associated with retroviral entry into cells, methods of identifying the same, and diagnostic and therapeutic uses thereof

Abstract: The present invention provides two new HIV/SIV translocation promoting agents, Bonzo and BOB. The present invention also provides the amino acid and DNA sequences of human, African green monkey, and pigtail macaque of the receptor protein Bonzo. Mammalian cells transfected with Bonzo and/or BOB and human CD4 as well as antibodies to the receptor Bonzo are also included. Furthermore, a method of identifying other such translocation promoting agents is also disclosed. Diagnostic and therapeutic uses of the translocation promoting agents of the present invention are also provided.

Inventors: Littman; Dan R. (New York, NY), Deng; Hongkui (Shrewsbury, MA), Unutmaz; Derya (New York, NY), Kewalramani; Vineet N. (Rockford, IL)

Assignee: New York University

International Classification: G01N 33/74 (20060101); G01N 33/569 (20060101); C12Q 001/70 (); C12Q 003/00 (); C12Q 001/00 (); G01N 033/53 (); G01N 033/567 ()

Expiration Date: 06/26/2018