Patent Number: 6,251,589

Title: Method for diagnosing spinocerebellar ataxia type 2 and primers therefor

Abstract: A method for specifically diagnosing spinocerebellar ataxia type 2 (SCA2) is disclosed. In the method of the present invention, PCR is carried out using a first primer which hybridizes with a part of the nucleotide sequence shown in SEQ ID NO:1, a second primer which hybridizes with a part of the nucleotide sequence shown in SEQ ID NO:3, and a test DNA as a template, and the number of CAG repeats is measured in the amplified PCR product. Since the numbers of CAG repeat in the genes of SCA2 patients are not less than 35 while those of normal individuals are 15 to 24, diagnosis of SCA2 can be carried out by the method of the present invention.

Inventors: Tsuji; Shoji (Niigata, JP), Sanpei; Kazuhiro (Niigata, JP)

Assignee: SRL, Inc.

International Classification: C12Q 1/68 (20060101); C12Q 001/68 ()

Expiration Date: 06/26/2018