Patent Number: 6,251,599

Title: Stabilized nucleic acid compositions and methods of preparation and use thereof

Abstract: Preparations of nucleic acid condensates and compositions containing such condensates are provided. The nucleic acid condensates are in the form of small particles that are stable when subjected to destabilizing conditions such as lyophilizing, freeze-thawing, and prolonged liquid storage. These compositions may be used to deliver nucleic acid to cells.

Inventors: Chen; Xian (San Diego, CA), Ma; Chenglie (San Diego, CA), D'Andrea; Mark J. (Carlsbad, CA)

Assignee: Selective Genetics, Inc.

International Classification: A61K 9/19 (20060101); A61K 47/48 (20060101); A61K 48/00 (20060101); C12N 15/87 (20060101); A61K 47/26 (20060101); C12Q 001/68 ()

Expiration Date: 06/26/2018