Patent Number: 6,251,605

Title: Yeast cells having mutations in Cav1 and uses therefor

Abstract: The invention provides isolated yeast cells which comprise a mutation in an endogenous yeast CAV1 gene, which exhibit increased signaling via the pheromone response pathway. In a preferred embodiment, the cav1 mutant yeast cells of the invention also express a heterologous G protein coupled receptor that functionally couples to the pheromone response pathway. The instant yeast cells display enhanced sensitivity to ligand induced stimulation of heterologous G protein coupled receptors and, therefore, show improved properties in drug screening assays.

Inventors: Ostanin; Kirill (Shrub Oak, NY), Silverman; Lauren (Ossining, NY)

Assignee: Cadus Pharmaceutical Corporation

International Classification: C07K 14/37 (20060101); C07K 14/395 (20060101); C12Q 001/68 (); C12N 001/19 ()

Expiration Date: 06/26/2018