Patent Number: 6,251,611

Title: Method of determining volume dependent hypertension via reduction in phosphorylation

Abstract: A method of determining the presence of chronic volume dependent hypertension is provided wherein a determination is made as to whether there has been a substantial reduction in phosphorylation of the blood-derived protein or renal proximal brush border membrane protein and if such reduction exists concluding that chronic volume dependent hypertension exists in a patient. The method may advantageously be practiced by employing blood serum or blood plasma as the body specimen containing the protein in determining whether a patient has chronic volume dependent hypertension, a cellular component of the blood, such as a blood-derived protein coming from the plasma membrane of lymphocytes. The method may include subsequent therapeutic patient treatment. Related diagnostic apparatus is also provided.

Inventors: Puschett; Jules B. (New Orleans, LA)

Assignee: Tulane University Medical Center

International Classification: G01N 33/68 (20060101); G01N 033/53 (); G01N 031/00 (); G01N 033/48 (); C12N 011/02 ()

Expiration Date: 06/26/2018