Patent Number: 6,251,616

Title: Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response

Abstract: A method for screening for a pro-tumor immune response according to the present invention, the method comprises: contacting a clinical sample with one or more detector molecules for detecting, and then determining the amount of, mononuclear cell phenotype in the sample; and (b) comparing the amount of mononuclear cell phenotype determined in the sample to a reference value for the mononuclear cell phenotype; wherein a significant difference in the amount of mononuclear cell phenotype determined as compared to the reference value may be an indicator of the presence of a pro-tumor immune response. Also provided are assay kits for determining an amount of mononuclear cell phenotype in performing the methods according to the present invention.

Inventors: Barbera-Guillem; Emilio (Powell, OH), Nelson; M. Bud (Worthington, OH)

Assignee: BioCrystal Ltd.

International Classification: G01N 33/569 (20060101); G01N 033/574 (); G01N 033/53 (); G01N 033/555 (); G01N 033/567 ()

Expiration Date: 06/26/2018